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Azithromycin Tablet

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Active Ingredient (Generic Name): Azithromycin
Indication: Bacterial infections of the eye, Conjunctivitis, Bacterial infections
Manufacturer: Cipla Limited
Packaging: 3 tablets & 6 tablets in 1 strip
Delivery Time: 6 To 15 days
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Description

What is Azithromycin?

Azithromycin is used to treat bacterial infections by inhibiting bacterial protein synthesis. It is effective against many types of bacteria and is often prescribed for infections that are resistant to other antibiotics.

Azithromycin is a widely prescribed antibiotic belonging to the macrolide class of antibiotics. It is effective against a variety of bacterial infections and is known for its broad-spectrum activity, efficacy, and convenient dosing schedule.

Mechanism of Action

Azithromycin works by binding to the 50S ribosomal subunit of the bacterial ribosome. This binding inhibits the translocation process during protein synthesis, preventing the bacteria from producing essential proteins needed for their growth and replication. This action stops the bacteria from multiplying and helps the immune system clear the infection.

Dosage Forms

Azithromycin is available in several forms, including:

  • Tablets: Typically available in 250 mg, 500 mg, and 600 mg strengths.
  • Oral Suspension: A liquid form often used for children or those who have difficulty swallowing tablets, usually available in a concentration of 100 mg/5 ml or 200 mg/5 ml.
  • Injectable Form: For intravenous administration in hospital settings.

Indications

Azithromycin is used to treat a variety of bacterial infections, including:

  • Respiratory Infections: Such as pneumonia, bronchitis, and sinusitis.
  • Ear Infections: Including otitis media.
  • Skin Infections: Such as cellulitis and impetigo.
  • Sexually Transmitted Infections: Like chlamydia and gonorrhea.
  • Throat Infections: Including pharyngitis and tonsillitis.
  • Pelvic Inflammatory Disease (PID): In combination with other antibiotics.

Dosage and Administration

  • Adults: The typical dose is 500 mg on the first day, followed by 250 mg once daily for 4 days, totaling a 5-day course. The exact dosage and duration depend on the type of infection and its severity.
  • Children: The dosage is based on the child’s weight and the type of infection. It is often given as a liquid suspension for ease of administration.
  • Administration: Azithromycin should be taken with or without food. The tablets should be swallowed whole, not chewed or crushed.

Duration of Action

Azithromycin has a long half-life, allowing for once-daily dosing. It remains effective in the body for several days after the course of treatment has ended, which contributes to its effectiveness in treating infections.

Side Effects

Common side effects of azithromycin may include:

  • Gastrointestinal Issues: Nausea, vomiting, diarrhea, abdominal pain, and indigestion.
  • Allergic Reactions: Rash, itching, and in rare cases, severe allergic reactions like anaphylaxis.
  • Headache and Dizziness: Some individuals may experience headaches or dizziness.
  • Liver Effects: Elevated liver enzymes or hepatitis, though rare.

Serious side effects are rare but can include:

  • QT Prolongation: A potential heart rhythm disturbance that can lead to serious conditions like arrhythmias.
  • Severe Allergic Reactions: Such as swelling of the face or throat and difficulty breathing.

Precautions and Warnings

  • Allergies: Inform your healthcare provider if you have a history of allergies to macrolide antibiotics or any other medications.
  • Liver Disease: Use azithromycin with caution in individuals with liver impairment, as it can affect liver function.
  • Drug Interactions: Azithromycin may interact with other medications, including anticoagulants, anti-seizure medications, and certain antiarrhythmics. Always inform your healthcare provider about all medications and supplements you are taking.
  • Pregnancy and Breastfeeding: Azithromycin is generally considered safe during pregnancy and breastfeeding, but it should be used only if clearly needed and under medical supervision.

Storage

  • Tablets: Store at room temperature, away from moisture and heat. Keep them out of reach of children.
  • Oral Suspension: Once reconstituted, the suspension should be stored in the refrigerator and used within the time frame specified by the manufacturer, usually 10 days.

Important Considerations

  • Compliance: It is crucial to complete the full course of azithromycin as prescribed, even if symptoms improve before the medication is finished. This helps prevent the development of antibiotic-resistant bacteria.
  • Consultation: Always consult with a healthcare provider before starting azithromycin to ensure it is appropriate for your condition and to discuss any potential risks and benefits.

 

Here are some short FAQs about Azithromycin:

1. What is Azithromycin used for?

Answer: It is used to treat a variety of bacterial infections, including respiratory, ear, skin, and sexually transmitted infections.

2. How does it work?

Answer: It inhibits bacterial protein synthesis by binding to the ribosomal subunits, preventing bacteria from growing and reproducing.

3. What are the common doses of Azithromycin?

Answer: Common doses include 250 mg, 500 mg, and 600 mg tablets. The exact dose depends on the infection being treated.

4. How should it be taken?

Answer: It should be taken orally, with or without food. Tablets should be swallowed whole.

5. What are the common side effects of it?

Answer: Common side effects include nausea, diarrhea, abdominal pain, and headache.

6. Are there any serious side effects?

Answer: Serious side effects can include severe allergic reactions, liver problems, and heart rhythm issues (QT prolongation).

7. Can it be taken with other medications?

Answer: It can interact with certain medications. Inform your healthcare provider about all other medications you are taking.

8. Is it safe during pregnancy?

Answer: It is generally considered safe during pregnancy but should be used under medical supervision.

9. How should it be stored?

Answer: Store these tablets at room temperature, away from moisture and heat. Keep out of reach of children.

10. What should I do if I miss a dose?

Answer: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses.

 

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Summary

Azithromycin is a versatile and effective antibiotic used to treat a range of bacterial infections. Its convenient dosing schedule and long half-life make it a popular choice among both patients and healthcare providers. As with any medication, it should be used according to a healthcare provider’s instructions to ensure safety and effectiveness.

Additional information

mg

Azicip 250mg, Azicip 500mg

unit

30 Tablets, 60 Tablets, 90 Tablets

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